To produce to produce with other techniques of gene transfer in comparison electroporation site.

. to produce to produce with other techniques of gene transfer in comparison electroporation, a greater magnitude of clinical benefit in this aggressive and often fatal disease[ metastatic melanoma]. site .

– In other studies, the delivery of IL-12 in the form of recombinant protein caused significant toxicity The toxicity was reduced in this study in this study. The gene, the gene, the IL-12. – Local intratumoral injection of IL-12 plasmid[ without electroporation] in a recent independent phase I trial using the same plasmid as our study electroporation resulted in local tumor regression in five of 12 patients, but there was no change in seen untreated distant lesions .

. to produce to produce with other techniques of gene transfer in comparison electroporation, a greater magnitude of clinical benefit in this aggressive and often fatal disease[ metastatic melanoma]. site .

– In other studies, the delivery of IL-12 in the form of recombinant protein caused significant toxicity The toxicity was reduced in this study in this study. The gene, the gene, the IL-12. – Local intratumoral injection of IL-12 plasmid[ without electroporation] in a recent independent phase I trial using the same plasmid as our study electroporation resulted in local tumor regression in five of 12 patients, but there was no change in seen untreated distant lesions .

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